From Critical Care Medicine
Infectious Complications in Out-of-hospital Cardiac Arrest Patients in the Therapeutic Hypothermia Era
Nicolas Mongardon, MD; Sébastien Perbet, MD; Virginie Lemiale, MD; Florence Dumas, MD; Hélène Poupet, MD; Julien Charpentier, MD; Frédéric Péne, MD; Jean-Daniel Chiche, MD; Jean-Paul Mira, MD; Alain Cariou, MD
Posted: 06/01/2011; Crit Care Med. 2011;39(6):1359-1364.
© 2011 Lippincott Williams & Wilkins
Objectives: Infectious complications are frequently reported in critically ill patients, especially after cardiac arrest. Recent and widespread use of therapeutic hypothermia has raised concerns about increased septic complications, but no specific reappraisal has been performed. We investigated the infectious complications in cardiac arrest survivors and assessed their impact on morbidity and long-term outcome.
Design: Retrospective review of a prospectively acquired intensive care unit database.
Setting: A 24-bed medical intensive care unit in a French university hospital.
Patients: Between March 2004 and March 2008, consecutive patients admitted for management of resuscitated out-of-hospital cardiac arrest were considered. Patients dying within 24 hrs were excluded. All patients’ files were reviewed to assess the development of infection…..
Conclusions: Infectious complications are frequent after cardiac arrest and may be even more frequent after therapeutic hypothermia. Despite increase in care costs, long-term and clinically relevant outcomes do not seem to be impaired. This should not discourage the use of therapeutic hypothermia in cardiac arrest survivors.
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