Articolo Scientifico Bilingue
Caso Clinico/Case Report Transfusion-Related Acute Lung Injury (Trali)
Giovanni Benigni, Maurizio Greco, Livio Cocco, Fernanda Cirillo, Monica De Caro, R.E.Sergio Landi, Rosanna Lomuto, Erminio Pace, Marianna Raffa
Viene descritto il caso clinico di una paziente con una grave sindrome respiratoria insorta entro poche ore dal ricorso ad abbondanti trasfusioni di emocomponenti, quali Plasma Fresco Congelato (PFC) ed Emazie Concentrate (EC). Tale sindrome viene didatticamente definita come Transfusion-Related Acute Lung Injury (TRALI) ed è caratterizzata da dispnea, ipossia, ipotensione arteriosa, edema polmonare bilaterale non cardiogeno e febbre. I sintomi descritti sono strettamente correlati all’accumularsi di liquido nel tessuto polmonare, e la loro gravità dipende dal grado di ipossia determinatosi nel paziente. Attraverso la descrizione del nostro caso clinico e la revisione della letteratura esistente vogliamo chiarire al lettore i criteri di diagnosi e di trattamento della TRALI.
Abstract. – We relate about a case of a patient with a severe lung injury following a recent transfusion of a great deal of blood products, like Fresh Frozen Plasma (FFP) and packed red blood cells (PRC).
This syndrome is commonly definited as a Transfusion-Related Acute Lung Injury (TRALI) and is clinically characterized by dispnea, hypoxemia, hypotension, a sudden bilateral non cardiogenic pulmonary edema and fever. The clinical manifestation of TRALI is strictly related to the amount of lung’s fluid overload, and it’s severity depends from the entity of patient’s Hypoxemia. The description of our clinical case and the following review about the recent advances in our Knowledge of the TRALI can guide the reader to a best recognition and clinical management of this adverse syndrome.
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Timeoutintensiva.it, N°8, Technè, Dicembre 2008
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